Medical Director-Nephrology/Genetic diseases (Translational Medicine)
Jobbeschreibung
Basel, Basel-Stadt, Schweiz
Novartis
03.05.2024
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About the roleOver 2 million! That’s the number of people worldwide
currently relying on dialysis or kidney transplants to survive.
However, this number represent less than 10% of the actual number
requiring treatment for their kidney diseases.As a Translational
Medicine Expert (TME), you will provide medical and scientific
expertise that drives the success of early drug development, global
clinical studies, and strategies to achieve clinical Proof-of-Concept
in the Nephrology disease area, and to progress towards new treatments
for unmet medical needs.The position can be in Basel (Switzerland) or
Cambridge, Massachusetts (USA); please state your preference within
your application letter. Basel is preferred for co-location with most
of the disease area scientists.About Translational Medicine at
NovartisTranslational Medicine is a global group of scientists and
physicians working at the pre-clinical and early clinical stage of
drug discovery.Our physician-scientist discovery & profiling (TMDP)
group drives innovative and cutting–edge science from discovery to the
market through the selection, profiling and effective global
development of successful medicines. The group closes the gap between
preclinical research and clinical development and integrates clinical
science into the discovery and preclinical development phase. Our
Translational Medicine concepts are driven by medical needs of the
patient and the concept of personalized medicine, tailoring the drug,
its dose and dosing regimen in such way to the patient that the
clinical response is optimal in terms of efficacy and safety.We focus
from identification of drug targets (molecular pathways relevant to
disease) up to the completion of Proof-of-Concept (Phase 2a studies).
Our Translational Medicine Experts (TME) are part of preclinical
project teams in all drug discovery phases and help design the pathway
for First in Human (FIH) studies (healthy volunteer) that bridge to
studies in the patient population. They have the comprehensive
responsibility for designing and executing the early clinical drug
development phase together with a project team from researcher,
biomarkers, biostatistics, modelling & simulation, toxicology,
technical experts and the clinical trial teams.After the completion of
a successful Phase 2a study the drug progresses to full development
for Phase 2b and Phase 3 study design and further drug
development.Your role in Translational Medicine- In collaboration with
your Translational Medicine Head and other line function experts,
develop high value decision-strategies for the Translational Medicine
component of drug development projects through the Proof-of-Concept
phase- Lead global project teams through Phase 2 to drive
implementation of the project strategy; participate in
cross-functional project meetings through the program life cycle from
target review to registration- Responsible for clinical portions of
the Integrated Development Plan through Phase 2- Responsible for
implementation of early clinical studies by providing medical and
scientific leadership and expertise to all line functions on the
project team; this may include methodology studies to identify and
validate novel endpoints for early decision making- Participate in
analysis of studies and present results to relevant decision boards-
Medical monitor for one or more global clinical studies- Communicate
clinical team matters to project teams and relevant decision boards-
Convene relevant (internal and external) leaders together to consider
the proposed development strategy- Evaluate clinical centers and
foster communication with collaborating investigators- Oversee
publication and external presentation of clinical study results-
Accountable for compound related biomarker strategies in close
collaboration with biomarker experts- In collaboration with research
scientists, identify, develop and implement strategy for pre-clinical
support of program-related objectives; this may include assessment of
medical need, proposal of clinical development pathways, and review of
pre-clinical data for clinical implications, and other relevant
activities- Participate in team presentations to health authorities as
clinical development expert- Prepare and implement disease area or
project-specific trainings and educational programs for colleagues
from Translational Medicine and other line functions; mentor
Translational Medicine colleagues on scientific, clinical, and drug
development issues- Contribute to initiatives that drive innovation,
quality, and efficiency across Translational MedicineCommitment to
Diversity & Inclusion:We are committed to building an outstanding,
inclusive work environment and diverse teams representative of the
patients and communities we serve.Role RequirementsWhat you’ll bring
to the role- Medical Degree, Board certified Nephrologist- PhD-level
basic science supported with high quality publications; a completed
postdoctoral fellowship is strongly preferred- Adult Nephrology
expertise is preferred to bring additional skills to the team-
Expertise in genetically inherited kidney / inflammasome /
inflammatory diseases; alternatively, cell therapies / rheumatologic
diseases- Experienced clinician treating relevant patient groups at an
academic medical center or private medical practice group- Experience
performing in a similar role within an Pharmaceutical research company
is preferred, otherwise a Clinical Research Organization or academic
medical center- Significant evidence of successful collaboration with
expert disease research scientists- Used to leading complex
cross-functional/matrix project teams- Advanced/business-level/fluent
EnglishYour behavioural characteristics- Strategic thinker: you have
created major innovations, networked with and influenced external
medical leaders with your clear and logical presentation of complex
strategic issues- Results-driven self-starter and decision taker-
Strong cooperative team player, flexible in a changing environment-
Good planning, prioritisation, problem solving and organisational
skills- Resilient, energetic, and enthusiastic; responding
constructively to challenging new ideas and inputThis position is
written for Director level; however, we can hire Associate Director
that may have less established scientific and/or clinical trial
experience but has already demonstrated new thinking/innovative
approaches within their career so far, as well as more experienced
Executive Directors.Why Novartis?766 million lives were touched by
Novartis medicines in 2021, and while we’re proud of this, we know
there is so much more we could do to help improve and extend people’s
lives.We believe new insights, perspectives and ground-breaking
solutions can be found at the intersection of medical science and
digital innovation. That a diverse, equitable and inclusive
environment inspires new ways of working.DivisionBiomedical Research
Business UnitTranslational Medicine Work LocationBasel Company/Legal
EntityNovartis Pharma AGFunctional AreaResearch & Development Job
TypeFull TimeEmployment TypeRegular Shift WorkNoEarly TalentNoCountry:
Switzerland
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Medical Director-Nephrology/Genetic Diseases (Translational Medicine)
Novartis
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