Medical Director - Translational Medicine (Neuroscience)
Jobbeschreibung
Basel, Basel-Stadt, Schweiz
Novartis
27.04.2024
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About the role2 Billion plus people are affected by diseases of the
nervous system having a dramatic impact on patients and families
around the world. Neurologic and psychiatric diseases remain as some
of the largest challenges in medicine. Novartis is committed to
changing the landscape by developing transformative treatments for
important neuroscience disorders.As part of the Neuroscience (NS)
departments at Novartis, you will help to develop therapies for
patients with neuroimmunological disorders including multiple
sclerosis. You will provide medical and scientific leadership and
expertise in a role that significantly affects the entire Novartis NS
pipeline. You will drive the success of both early and late stage
global programs. You will provide scientific expert assessments and
support for in-licensing opportunities, including due diligences.Your
responsibilities will include:1. Translational Medicine (early
clinical projects):• Develop high value decision-strategies for the
Translational Medicine component of drug development projects from
Research to clinical Proof of Concept or Proof of Mechanism in a
single or multiple indications. • Develop and implement study
protocols for different types of clinical studies (First in Human,
Proof of Concept, mechanistic and safety studies), and other documents
such as investigators brochures.• Responsible for clinical monitoring
and integrated safety data review during and after the live phase of a
study• Represent clinical Translational Medicine aspects to Health
Authorities and other stakeholders (e.g. payers, patient advocacy
groups)• Innovation: Champion and drive new clinical compound
characterization opportunities and profiling approaches2.
Translational Medicine (late-stage clinical projects):In collaboration
with the respective Translational Medicine Therapeutic Area Head:•
Responsible for implementing studies during the Proof of Concept phase
by providing medical and scientific leadership and expertise to all
line functions on the project team. This may include methodology
studies to identify and validate novel endpoints for early decision
making in Proof of Concept studies.• Communicate clinical team matters
to Global Project Teams, relevant BioMedical Research and Development
boards, and other Novartis Boards as required.• Evaluate clinical
centers and foster communication with crucial collaborating
investigators, regulatory authorities, and other stakeholders• The
work environment is in a matrix structure with cross-functional
members from Translational Medicine, Biomedical Research and
Development.Impact of this role?• Design and implementation of early
Clinical Development Plan and studies according to the Integrated
Development Plan / Clinical Development Plan / Clinical Pharmacology
Plan enabling efficient and rational decision-making, high probability
of fast drug registration, favorable drug label and high
competitiveness of compounds• This role has a key impact on the entire
Novartis pipeline, transitioning programs from preclinical through
early clinical and ultimately to full development via the Proof of
Concept mechanism, and driving the program after Proof of Concept by
delivering key Profiling data to support regulatory submissions• As a
recognized specialist in Neuroimmunology, you drive the project team
clinical strategy. Works globally across various Novartis divisions as
well as country organizations as appropriateCommitment to Diversity &
Inclusion:We are committed to building an outstanding, inclusive work
environment and diverse teams representative of the patients and
communities we serve.Role RequirementsWhat you will bring to the
role:• Medical Degree and advanced training in neuroimmunology • An
expertise in translational or laboratory research. PhD preferred but
not required• Record of drug submissions / approval and / or high
quality publications in international scientific journals.• Previous
relevant & significant clinical study experience: either from
pharma/biotech leading early phase clinical trials; a senior role
within a CRO responsible for managing the medical relationship with
Sponsors; from a relevant academic medical center with PI & co-PI
clinical trial experience.• Business fluent in English (written and
spoken)Why Novartis?766 million lives were touched by Novartis
medicines in 2021, and while we’re proud of this, we know there is so
much more we could do to help improve and extend people’s lives.We
believe new insights, perspectives and ground-breaking solutions can
be found at the intersection of medical science and digital
innovation. That a diverse, equitable and inclusive environment
inspires new ways of working.We believe our potential can thrive and
grow in an unbossed culture underpinned by integrity, curiosity and
flexibility. And we can reinvent what's possible, when we collaborate
with courage to aggressively and ambitiously tackle the world’s
toughest medical challenges. Because the greatest risk in life, is the
risk of never trying!Imagine what you could do here at
Novartis!DivisionBiomedical Research Business UnitTranslational
Medicine Work LocationBasel Company/Legal EntityNovartis Pharma
AGFunctional AreaResearch & Development Job TypeFull TimeEmployment
TypeRegular Shift WorkNoEarly TalentNoCountry: Switzerland
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